Building up Pt II −Thiosemicarbazone−Lysine−sC18 Conjugates

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Water soluble, cyclometalated Pt(ii)-Ln(iii) conjugates towards novel bimodal imaging agents.

Facile conjugation of a luminescent cyclometalated Pt(II) complex with a DO3A-derived Gd(III) moiety yields a hybrid species with visible luminescence and enhanced relaxivity.

متن کامل

Synthesis and characterization of Pt(IV) fluorescein conjugates to investigate Pt(IV) intracellular transformations.

Pt(IV) anticancer compounds typically operate as prodrugs that are reduced in the hypoxic environment of cancer cells, losing two axial ligands in the process to generate active Pt(II) species. Here we report the synthesis of two fluorescent Pt(IV) prodrugs of cisplatin in order to image and evaluate the Pt(IV) reduction process in simulated and real biological environments. Treatment of the co...

متن کامل

Novel Pt(II) Complex and Its Pd(II) Aanalogue. Synthesis, Characterization, Cytotoxicity and DNA-interaction

The ability of small molecules to perturb the natural structure and dynamics of nucleic acids is intriguing and has potential applications in cancer therapeutics. This work reports the synthesis, characterization, cytotoxicity and DNA-binding studies of two cytotoxic and intercalative [M(bpy)(pyrr-dtc)]NO3 complexes (where M = Pt(II) and Pd(II), bpy = 2,2´-bipyridine and pyrr-dtc = p...

متن کامل

Building up original evidence

American researchers are unfamiliar. Even when Japanese contributions are just as good as those from America, the journals have no choice but to allot their space to the latter. If Japanese researchers want to report their own research overseas in the same fields as ours, then Japanese academic societies will have to publish their own journals in English.” World-famous academic journals in Engl...

متن کامل

Building up biology

In 2005, Thomas Knight declared that “biology will never be the same” in describing research from Drew Endy and colleagues that extended engineering terminology such as ‘refactoring’ and ‘parts’ to a biological context (Mol. Syst. Biol. 1, 2005.0020, 2005). By then, Elowitz’s and Leibler’s foundational ‘repressilator’ study, in which three transcriptional repressors were integrated into an arti...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: ChemBioChem

سال: 2020

ISSN: 1439-4227,1439-7633

DOI: 10.1002/cbic.202000564